1-Acetamido-3-(4'-fluoro-4-biphenylyl)-butane → 3-(4'-Fluoro-4-biphenylyl)butylamine

HRID 2420616Notes

Reaction equation

HRID 2420616 reaction equation
C([NH:4][CH2:5][CH2:6][CH:7]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)[CH3:8])(=O)C>[OH-].[K+]>[F:21][C:18]1[CH:17]=[CH:16][C:15]([C:12]2[CH:13]=[CH:14][C:9]([CH:7]([CH3:8])[CH2:6][CH2:5][NH2:4])=[CH:10][CH:11]=2)=[CH:20][CH:19]=1

Participants

3

Reactant 1

HCID 203027051-Acetamido-3-(4'-fluoro-4-biphenylyl)-butane

Product 1

HCID 203021083-(4'-Fluoro-4-biphenylyl)butylamine

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

A solution of 28.5 g of 1-acetamido-3-(4'-fluoro-4-biphenylyl)-butane in 800 ml of 10% methanolic KOH solution is boiled for 48 hours. The solution is concentrated and worked up using water and ether to give 3-(4'-fluoro-4-biphenylyl)-butylamine; hydrochloride, m.p. 222° - 224°.

Workup

  1. concentrationThe solution is concentrated

Sources & evidence

ORD record
ord-a471968d826c439f961a6074a8a2cde7
Source dataset
uspto-grants-1978_08
Patent number
US04110447

Reaction notes

Loading…