反应详情

6,8-Difluoro-3-[2-(6-fluoro-3-pentylchroman-7-yl)vinyl]-2H-chromene is dissolved in THF and hydrogenated to completion on a palladium/active carbon catalyst. The catalyst is filtered off, the solution is evaporated, the residue is filtered through silica gel with toluene/heptane (3:2), and the crude product is recrystallised from n-heptane at −25° C., giving colourless crystals of m.p. 84° C.

1. filtrationThe catalyst is filtered off
2. customthe solution is evaporated
3. filtrationthe residue is filtered through silica gel with toluene/heptane (3:2)
4. customthe crude product is recrystallised from n-heptane at −25° C.
5. customgiving colourless crystals of m.p. 84° C.