Hydrochloric Acid → HCID 59202348, compound

HRID 2420659Notes

Reaction equation

HRID 2420659 reaction equation
[OH-].[Na+].[F:3][C:4]1[CH:15]=[C:14]([O:16][CH2:17][C:18]#[CH:19])[C:13]([F:20])=[CH:12][C:5]=1[C:6]([O:8]CC#C)=[O:7].Cl>CO>[F:3][C:4]1[CH:15]=[C:14]([O:16][CH2:17][C:18]#[CH:19])[C:13]([F:20])=[CH:12][C:5]=1[C:6]([OH:8])=[O:7]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59202333HCID 59202333, compound

Product 1

HCID 59202348HCID 59202348, compoundYield 61.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

To a mixture of 20 ml of methanol and 20 ml of a 15% aqueous sodium hydroxide solution was added 7.3 g of 2-propynyl 2,5-difluoro-4-(2-propynyloxy)benzoate, and the mixture was stirred at 50° C. for 2 hours. The reaction mixture was added to hydrochloric acid, and a produced solid was collected by filtration. The solid was dried and then washed with hexane, and 3.8 g of 2,5-difluoro-4-(2-propynyloxy)benzoic acid was obtained.

Workup

  1. filtrationa produced solid was collected by filtration
  2. customThe solid was dried
  3. washwashed with hexane

Sources & evidence

ORD record
ord-b73191bf89ff488fab854a86b464edb7
Source dataset
uspto-grants-2011_06
Patent number
US07956010B2

Reaction notes

Loading…