Toluene → HCID 59202351, compound

HRID 2420660Notes

Reaction equation

HRID 2420660 reaction equation
C1(C)C=CC=CC=1.[F:8][C:9]1[CH:17]=[C:16]([O:18][CH2:19][C:20]#[CH:21])[C:15]([F:22])=[CH:14][C:10]=1[C:11](O)=[O:12].S(Cl)([Cl:25])=O>CN(C=O)C>[F:8][C:9]1[CH:17]=[C:16]([O:18][CH2:19][C:20]#[CH:21])[C:15]([F:22])=[CH:14][C:10]=1[C:11]([Cl:25])=[O:12]

Participants

5

Reactant 3

HCID 1140TolueneHCID 24386Thionyl ChlorideHCID 59202348HCID 59202348, compound

Product 1

HCID 59202351HCID 59202351, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To 20 ml of toluene were added 1.4 g of 2,5-difluoro-4-(2-propynyloxy)benzoic acid, 0.8 ml of thionyl chloride and 10 mg of DMF, and the mixture was heated to reflux for 2 hours. Then, the reaction mixture was concentrated under reduced pressure, and 1.5 g of 2,5-difluoro-4-(2-propynyloxy)benzoyl chloride was obtained.

Workup

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 2 hours
  3. concentrationThen, the reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-f6219d76094042d1be9e510953063fcd
Source dataset
uspto-grants-2011_06
Patent number
US07956010B2

Reaction notes

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