Hydrochloric Acid → 12-Aminododecanoic acid (3-dimethylaminopropyl)amide dihydrochloride

HRID 2420748Notes

Reaction equation

HRID 2420748 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19](=[O:27])[NH:20][CH2:21][CH2:22][CH2:23][N:24]([CH3:26])[CH3:25])(C)(C)C.[ClH:29]>>[ClH:29].[ClH:29].[CH3:26][N:24]([CH3:25])[CH2:23][CH2:22][CH2:21][NH:20][C:19](=[O:27])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][NH2:7]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86634234[11-(3-Dimethylaminopropylcarbamoyl)undecyl]carbamic acid tert-butyl ester

Product 1

HCID 8663423512-Aminododecanoic acid (3-dimethylaminopropyl)amide dihydrochloride

Procedure

[11-(3-Dimethylaminopropylcarbamoyl)undecyl]carbamic acid tert-butyl ester (4) (0.087 g, 0.22 mmol) was treated with HCl (4 M in dioxane, 2 mL, 8 mmol) and the mixture stirred at room temperature for 14 hours. The reaction was then concentrated in vacuo and further dried under high vacuum. The resulting white solid (0.081 g, 99%) was used directly without further purification. m/z (ESI) 300 [C17H37N3O+H]+.

Workup

  1. concentrationThe reaction was then concentrated in vacuo
  2. customfurther dried under high vacuum
  3. customThe resulting white solid (0.081 g, 99%) was used directly without further purification

Sources & evidence

ORD record
ord-77089859a8254d7b8d158b17b5d7cf17
Source dataset
uspto-grants-2011_06
Patent number
US07956059B2

Reaction notes

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