Hydrochloric Acid → 12-Aminododecanoic acid amide hydrochloride

HRID 2420751Notes

Reaction equation

HRID 2420751 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19](=[O:21])[NH2:20])(C)(C)C.[ClH:23]>>[ClH:23].[NH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([NH2:20])=[O:21]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 21103219(11-Carbamoylundecyl)carbamic acid tert-butyl ester

Product 1

HCID 8663423712-Aminododecanoic acid amide hydrochloride

Procedure

[(11-Carbamoylundecyl)carbamic acid tert-butyl ester (7) (0.085 g, 0.27 mmol) was treated with HCl (4 M in dioxane, 2 mL, 8 mmol) at room temperature for 14 hours. The reaction mixture was concentrated in vacuo and further dried under high vacuum. The white solid (0.068 g, 99%) was used directly without further purification: m/z (ESI) 215 [C12H26N2O+H]+.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customfurther dried under high vacuum
  3. customThe white solid (0.068 g, 99%) was used directly without further purification

Sources & evidence

ORD record
ord-90c188506b9f43b9985ee6ead1b629bc
Source dataset
uspto-grants-2011_06
Patent number
US07956059B2

Reaction notes

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