Hydrochloric Acid → 12-Amino-1-piperazin-1-yl-dodecan-1-one dihydrochloride

HRID 2420754Notes

Reaction equation

HRID 2420754 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:34])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][NH:26]C(OC(C)(C)C)=O)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:35]>>[ClH:35].[ClH:35].[NH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][C:14]([N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)=[O:34]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 672154104-(12-tert-Butoxycarbonylaminododecanoyl)piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 6721532412-Amino-1-piperazin-1-yl-dodecan-1-one dihydrochloride

Procedure

4-(12-tert-Butoxycarbonylaminododecanoyl)piperazine-1-carboxylic acid tert-butyl ester (10) (464 mg, 0.96 mmol) was treated with HCl (4 M in dioxane, 8 mL, 32 mmol) at room temperature for 14 hours. The reaction mixture was concentrated in vacuo and further dried under high vacuum. The white solid (342 mg, 99%) was used directly without further purification: m/z ESI 284 [C16H33N3O+H]+.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customfurther dried under high vacuum
  3. customThe white solid (342 mg, 99%) was used directly without further purification

Sources & evidence

ORD record
ord-ee35348cd6c347ecbb4f82236e331d59
Source dataset
uspto-grants-2011_06
Patent number
US07956059B2

Reaction notes

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