Furfurylamine → HCID 67214769, compound

HRID 2420779Notes

Reaction equation

HRID 2420779 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([NH:13][C:14]3[CH:15]=[C:16]([CH:20]=[CH:21][CH:22]=3)[C:17]([OH:19])=O)[N:8]=2)[CH:2]=1.CC1C=CC(C(O)=O)=CC=1NC1N=C(C2C=NC=CC=2)C=CN=1.[CH3:46][C:47]1[N:48]=[CH:49][N:50]([C:52]2[CH:53]=[C:54]([C:59]([F:62])([F:61])[F:60])[CH:55]=[C:56]([NH2:58])[CH:57]=2)[CH:51]=1.C(N)C1OC=CC=1>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([NH:13][C:14]3[CH:15]=[C:16]([CH:20]=[CH:21][CH:22]=3)[C:17]([NH:58][C:56]3[CH:57]=[C:52]([N:50]4[CH:51]=[C:47]([CH3:46])[N:48]=[CH:49]4)[CH:53]=[C:54]([C:59]([F:62])([F:61])[F:60])[CH:55]=3)=[O:19])[N:8]=2)[CH:2]=1

Participants

5

Reactant 4

HCID 3438FurfurylamineHCID 10039959HCID 10039959, compoundHCID 104028804-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acidHCID 120028253-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Product 1

HCID 67214769HCID 67214769, compound

Procedure

Utilising the procedure described in example 1, but employing 3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-benzoic acid in lieu of 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-benzoic acid and 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine in lieu of furfurylamine, afforded the title compound as Pale-yellow crystalline solid, m.p. 264-266° C.

Sources & evidence

ORD record
ord-4caa78c34fd84fa1b6ddbcc7b73a8cc0
Source dataset
uspto-grants-2011_06
Patent number
US07956053B2

Reaction notes

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