Morpholine → 1-[1-(4-Chlorophenyl)cyclobutyl]-7-[3-(morpholin-4-ylsulfonyl)propoxy]-1,2,3,4-tetrahydroisoquinoline hydrochloride

HRID 242083Notes

Reaction equation

HRID 242083 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:12]3[C:21]4[C:16](=[CH:17][CH:18]=[C:19]([O:22][CH2:23][CH2:24][CH2:25][S:26](Cl)(=[O:28])=[O:27])[CH:20]=4)[CH2:15][CH2:14][N:13]=3)[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[NH:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1>>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH:12]3[C:21]4[C:16](=[CH:17][CH:18]=[C:19]([O:22][CH2:23][CH2:24][CH2:25][S:26]([N:30]5[CH2:35][CH2:34][O:33][CH2:32][CH2:31]5)(=[O:28])=[O:27])[CH:20]=4)[CH2:15][CH2:14][NH:13]3)[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 582461963-({1-[1-(4-Chlorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-yl}oxy)propane-1-sulfonyl chloride

Product 1

HCID 444655521-[1-(4-Chlorophenyl)cyclobutyl]-7-[3-(morpholin-4-ylsulfonyl)propoxy]-1,2,3,4-tetrahydroisoquinoline hydrochloride

Procedure

The compound was prepared analogously to example 82 from 3-({1-[1-(4-chlorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-yl}oxy)propane-1-sulfonyl chloride using morpholine in place of 1-propylamine.

Sources & evidence

ORD record
ord-9be73020f7d5450fbf894119868f6b91
Source dataset
uspto-grants-2014_02
Patent number
US08653100B2

Reaction notes

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