Hydrochloric Acid → HCID 66869229, compound

HRID 242096Notes

Reaction equation

HRID 242096 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:11]3[C:20]4[C:15](=[CH:16][CH:17]=[C:18]([O:21][CH2:22][CH2:23][NH:24]C(=O)OC(C)(C)C)[CH:19]=4)[CH2:14][CH2:13][N:12]=3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl>COC>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([C:11]3[C:20]4[C:15](=[CH:16][CH:17]=[C:18]([O:21][CH2:22][CH2:23][NH2:24])[CH:19]=4)[CH2:14][CH2:13][N:12]=3)[CH2:9][CH2:10]2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86653003HCID 86653003, compound

Product 1

HCID 66869229HCID 66869229, compound

Reagents, catalysts & solvents 1

HCID 8254Dimethyl EtherSolvent

Procedure

A solution of tert-butyl [2-({1-[1-(4-chlorophenyl)cyclopropyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethyl]carbamate (440 mg, 1 mmol) methylenehloride (10 ml) was treated with 5N HCl in dimethylether (0.5 ml) and stirred over night at room temperature. The solvent was removed, the residue triturated with diisopropyl ether and the insoluble slid collected. Yield: 370 mg (0.98 mmol, 98%)

Workup

  1. customThe solvent was removed
  2. customthe residue triturated with diisopropyl ether
  3. customthe insoluble slid collected

Sources & evidence

ORD record
ord-44887adbecb4400aaa8985ed7bfaca0b
Source dataset
uspto-grants-2014_02
Patent number
US08653100B2

Reaction notes

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