Hydrogen Bromide → HCID 178419267, compound

Participants

Reaction Steps

4-(2-Aminoethyl)-2-methoxypyridine dihydrochloride (225 mg, 1.00 mmol) synthesized in Reference Example 12 was mixed with 48% hydrobromic acid (3.0 mL) and acetic acid (3.0 mL), and the mixture was heated under reflux for 4 hours. The reaction mixture was concentrated under reduced pressure to give 4-(2-aminoethyl)-2-hydroxypyridine dihydrobromide (150 mg, yield 50%).

Provenance & Evidence