Hydrogen Bromide → HCID 178419267, compound

HRID 2420998Notes

Reaction equation

HRID 2420998 reaction equation
Cl.Cl.[NH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][N:9]=[C:8]([O:12]C)[CH:7]=1.[BrH:14]>C(O)(=O)C>[BrH:14].[BrH:14].[NH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][N:9]=[C:8]([OH:12])[CH:7]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 67251344HCID 67251344, compound

Product 1

HCID 178419267HCID 178419267, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

4-(2-Aminoethyl)-2-methoxypyridine dihydrochloride (225 mg, 1.00 mmol) synthesized in Reference Example 12 was mixed with 48% hydrobromic acid (3.0 mL) and acetic acid (3.0 mL), and the mixture was heated under reflux for 4 hours. The reaction mixture was concentrated under reduced pressure to give 4-(2-aminoethyl)-2-hydroxypyridine dihydrobromide (150 mg, yield 50%).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 4 hours
  3. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-03edd1ffe984446eb4613a177274a4e1
Source dataset
uspto-grants-2011_06
Patent number
US07956060B2

Reaction notes

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