2-Oxo-4-(trifluoromethyl)-2,3-dihydro-1,3-thiazole-5-carboxylic acid → HCID 11409939, compound

HRID 2421017Notes

Reaction equation

HRID 2421017 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[Cl:21])[O:5][CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][C@H:13]([OH:17])[CH2:14][NH:15][CH3:16])[CH2:8][CH2:7]1.[O:22]=[C:23]1[NH:27][C:26]([C:28]([F:31])([F:30])[F:29])=[C:25]([C:32]([OH:34])=O)[S:24]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[Cl:21])[O:5][CH:6]1[CH2:7][CH2:8][N:9]([CH2:12][C@H:13]([OH:17])[CH2:14][N:15]([CH3:16])[C:32]([C:25]2[S:24][C:23](=[O:22])[NH:27][C:26]=2[C:28]([F:29])([F:30])[F:31])=[O:34])[CH2:10][CH2:11]1

Participants

3

Reactant 2

HCID 198845762-Oxo-4-(trifluoromethyl)-2,3-dihydro-1,3-thiazole-5-carboxylic acidHCID 59295995HCID 59295995, compound

Product 1

HCID 11409939HCID 11409939, compoundYield 35.7%

Procedure

Prepared as Example 1 using (2R)-1-[4-(3,4-dichlorophenoxy)piperidin-1-yl]-3-(methylamino)propan-2-ol (150mg, 0.45 mmol) and 2-oxo-4-(trifluoromethyl)-2,3-dihydro-1,3-thiazole-5-carboxylic acid (0.096 g) to yield the title compound as a colourless solid (0.085 g).

Sources & evidence

ORD record
ord-c40601e38a1842d78fbdcf75d499d1ec
Source dataset
uspto-grants-2011_06
Patent number
US07956070B2

Reaction notes

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