HCID 178470516, compound → HCID 178524963, compound

HRID 2421023Notes

Reaction equation

HRID 2421023 reaction equation
[F:1][C:2]([F:16])([F:15])[CH2:3][S:4][C:5]1[NH:9][N:8]=[N:7][C:6]=1[C:10]([O:12]CC)=[O:11]>[OH-].[Na+]>[F:16][C:2]([F:1])([F:15])[CH2:3][S:4][C:5]1[NH:9][N:8]=[N:7][C:6]=1[C:10]([OH:12])=[O:11]

Participants

3

Reactant 1

HCID 178470516HCID 178470516, compound

Product 1

HCID 178524963HCID 178524963, compoundYield 104.5%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Conditions

Temperature
70 °C

Procedure

Ethyl 5-[(2,2,2-trifluoroethyl)thio]-1H-1,2,3-triazole-4-carboxylate (0.086 g) was suspended in 1N aqueous sodium hydroxide solution and heated at 70° C. for 3 h. The reaction mixture was filtered and then acidified with concentrated hydrochloric acid. Concentration in vacuo afforded a colourless solid which was washed with ice cold water to afford the subtitle compound (0.080 g)

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationConcentration in vacuo
  3. customafforded a colourless solid which
  4. washwas washed with ice cold water

Sources & evidence

ORD record
ord-c6b6909a29d44e6ea365c9c556e1acaa
Source dataset
uspto-grants-2011_06
Patent number
US07956070B2

Reaction notes

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