Ammonium Acetate → HCID 67215043, compound

HRID 2421027Notes

Reaction equation

HRID 2421027 reaction equation
[F:1][C:2]([F:18])([F:17])[CH2:3][C:4](=O)[CH2:5][C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7].C([O-])(=O)C.[NH4+:23]>C(O)C>[NH2:23]/[C:4](/[CH2:3][C:2]([F:18])([F:17])[F:1])=[CH:5]/[C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7]

Participants

4

Reactant 2

HCID 517165Ammonium AcetateHCID 67215591HCID 67215591, compound

Product 1

HCID 67215043HCID 67215043, compoundYield 33.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

Benzyl 5,5,5-trifluoro-3-oxopentanoate (2.1 g) in ethanol (15 mL) was treated with ammonium acetate (2 g). The mixture was heated at 80° C. for 18 h and was then concentrated in vacuo. Water and DCM were added. The organic phase was separated and washed with sodium bicarbonate solution and water and then dried over sodium sulphate and filtered. The solvent was concentrated in vacuo to yield the title compound as a colourless oil (0.71 g).

Workup

  1. concentrationwas then concentrated in vacuo
  2. additionWater and DCM were added
  3. customThe organic phase was separated
  4. washwashed with sodium bicarbonate solution and water
  5. dry with materialdried over sodium sulphate
  6. filtrationfiltered
  7. concentrationThe solvent was concentrated in vacuo

Sources & evidence

ORD record
ord-d5e3402f2a784d8a8c5f8993687a6088
Source dataset
uspto-grants-2011_06
Patent number
US07956070B2

Reaction notes

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