3-(2-(tert-Butoxy)-2-oxoethoxy)benzoic acid → Tert-butyl{3-[({(2r)-3-[4-(3,4-dichloro-2-methylphenoxy)piperidin-1-yl]-2-hydroxypropyl}amino)carbonyl]phenoxy}acetate

HRID 2421046Notes

Reaction equation

HRID 2421046 reaction equation
[C:1]([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12]([OH:14])=O)([CH3:4])([CH3:3])[CH3:2].[NH2:19][CH2:20][C@@H:21]([OH:39])[CH2:22][N:23]1[CH2:28][CH2:27][CH:26]([O:29][C:30]2[CH:35]=[CH:34][C:33]([Cl:36])=[C:32]([Cl:37])[C:31]=2[CH3:38])[CH2:25][CH2:24]1>>[C:1]([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:11]([C:12]([NH:19][CH2:20][C@@H:21]([OH:39])[CH2:22][N:23]2[CH2:28][CH2:27][CH:26]([O:29][C:30]3[CH:35]=[CH:34][C:33]([Cl:36])=[C:32]([Cl:37])[C:31]=3[CH3:38])[CH2:25][CH2:24]2)=[O:14])[CH:10]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 114140743-(2-(tert-Butoxy)-2-oxoethoxy)benzoic acidHCID 67215078(2R)-1-amino-3-[4-(3,4-dichloro-2-methylphenoxy)piperidin-1-yl]propan-2-ol

Product 1

HCID 131728946Tert-butyl{3-[({(2r)-3-[4-(3,4-dichloro-2-methylphenoxy)piperidin-1-yl]-2-hydroxypropyl}amino)carbonyl]phenoxy}acetate

Procedure

Prepared as for Example 15 Step 2 using 3-(2-tert-butoxy-2-oxoethoxy)benzoic acid [WO 00/78317 A1] and (2R)-1-amino-3-[4-(3,4-dichloro-2-methylphenoxy)piperidin-1-yl]propan-2-ol to yield the subtitle compound as a white solid (0.11 g).

Sources & evidence

ORD record
ord-5f0b33409807483a9a7eba3eee63af6e
Source dataset
uspto-grants-2011_06
Patent number
US07956070B2

Reaction notes

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