3-(2-(tert-Butoxy)-2-oxoethoxy)benzoic acid → Tert-butyl{3-[({(2r)-3-[4-(3,4-dichloro-2-methylphenoxy)piperidin-1-yl]-2-hydroxypropyl}amino)carbonyl]phenoxy}acetate

Participants

Role	Name	HCID	Charge
Reactant	3-(2-(tert-Butoxy)-2-oxoethoxy)benzoic acid	HCID 11414074	—
Reactant	(2R)-1-amino-3-[4-(3,4-dichloro-2-methylphenoxy)piperidin-1-yl]propan-2-ol	HCID 67215078	—
Product	Tert-butyl{3-[({(2r)-3-[4-(3,4-dichloro-2-methylphenoxy)piperidin-1-yl]-2-hydroxypropyl}amino)carbonyl]phenoxy}acetate	HCID 131728946	—

Reaction Steps

Prepared as for Example 15 Step 2 using 3-(2-tert-butoxy-2-oxoethoxy)benzoic acid [WO 00/78317 A1] and (2R)-1-amino-3-[4-(3,4-dichloro-2-methylphenoxy)piperidin-1-yl]propan-2-ol to yield the subtitle compound as a white solid (0.11 g).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07956070B2
Source dataset	uspto-grants-2011_06
ORD ID	ord-5f0b33409807483a9a7eba3eee63af6e
Source note	uspto-grants-2011_06