HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Trifluoroacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-butyl 4-(2-oxooctahydro-1H-benzimidazol-1-yl)piperidine-1-carboxylate | HCID 20768913 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Trifluoroacetic acid | HCID 6422 | — |
| Product | (3aS,7aS)-1-piperidin-4-yloctahydro-2H-benzimidazol-2-one | HCID 59025441 | — |
Reaction Steps
A solution tert-butyl 4-(2-oxooctahydro-1H-benzimidazol-1-yl)piperidine-1-carboxylate (1 g) in dichloromethane (20 mL) was added with TFA (5 mL) and stirred at room temperature for 1 hour. The solvent was removed under reduced pressure to provide the titled compound as its TFA salt. The salt was then transformed to freebase by MP-carbonate and used without any purification. MS (M+1): 224.25
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07956069B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-0ccf00eaf02140e8b0fb530e58359a08 |
| Source note | uspto-grants-2011_06 |