Hydrochloric Acid → HCID 131728948, compound

Participants

Reaction Steps

A 4N solution of hydrochloric acid in dioxane (1.0 mL, 4.0 mmol) was added to a solution of cis-(+/−)-tert-butyl 4-(2-oxooctahydro-1H-benzimidazol-1-yl)-1,4′-bipiperidine-1′-carboxylate (244 mg, 0.60 mmol) from Step A in dioxane (5 mL). The reaction was stirred at room temperature for 7 h and the mixture was concentrated in vacuo. The product (251 mg) was used directly for the next step without further purification. MS (M+1): 307.4

Provenance & Evidence