Hydrochloric Acid → HCID 131728948, compound

HRID 2421066Notes

Reaction equation

HRID 2421066 reaction equation
[ClH:1].[O:2]=[C:3]1[N:7]([CH:8]2[CH2:13][CH2:12][N:11]([CH:14]3[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]3)[CH2:10][CH2:9]2)[C@H:6]2[CH2:27][CH2:28][CH2:29][CH2:30][C@H:5]2[NH:4]1>O1CCOCC1>[ClH:1].[N:11]1([CH:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)[CH2:10][CH2:9][CH:8]([N:7]2[C@H:6]3[CH2:27][CH2:28][CH2:29][CH2:30][C@H:5]3[NH:4][C:3]2=[O:2])[CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59025418HCID 59025418, compound

Product 1

HCID 131728948HCID 131728948, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A 4N solution of hydrochloric acid in dioxane (1.0 mL, 4.0 mmol) was added to a solution of cis-(+/−)-tert-butyl 4-(2-oxooctahydro-1H-benzimidazol-1-yl)-1,4′-bipiperidine-1′-carboxylate (244 mg, 0.60 mmol) from Step A in dioxane (5 mL). The reaction was stirred at room temperature for 7 h and the mixture was concentrated in vacuo. The product (251 mg) was used directly for the next step without further purification. MS (M+1): 307.4

Workup

  1. concentrationthe mixture was concentrated in vacuo
  2. customThe product (251 mg) was used directly for the next step without further purification

Sources & evidence

ORD record
ord-3625e654feb448309b7d83c7602a6b2e
Source dataset
uspto-grants-2011_06
Patent number
US07956069B2

Reaction notes

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