1,4-Dioxane hydrochloride → HCID 59025420, compound

HRID 2421083Notes

Reaction equation

HRID 2421083 reaction equation
[O:1]=[C:2]1[CH2:10][C@@H:9]2[C@H:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)[N:3]1[CH:11]1[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]1.Cl.O1CCOCC1>CO>[NH:14]1[CH2:13][CH2:12][CH:11]([N:3]2[C@@H:4]3[C@H:9]([CH2:8][CH2:7][CH2:6][CH2:5]3)[CH2:10][C:2]2=[O:1])[CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59025416HCID 59025416, compound

Product 1

HCID 59025420HCID 59025420, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

tert-butyl 4-[(3aR,7aS)-2-oxooctahydro-1H-indol-1-yl]piperidine-1-carboxylate was dissolved in MeOH (25 mL) and 4M HCl/dioxane (5 mL) was added. The mixture stirred at room temperature then concentrated in vacuo to give the tile compound. MS (M+1): 223.26

Workup

  1. concentrationthen concentrated in vacuo
  2. customto give the tile compound

Sources & evidence

ORD record
ord-f87dbdfb2e2646619e81ee26ce0fb60f
Source dataset
uspto-grants-2011_06
Patent number
US07956069B2

Reaction notes

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