5-Methyl-3-phenyl-4-isoxazolecarbohydrazide → HCID 86613580, compound

HRID 2421185Notes

Reaction equation

HRID 2421185 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]([NH:15][NH2:16])=[O:14].[Cl:17][C:18]1[N:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:19]=1[C:20](O)=O>>[Cl:17][C:18]1[C:19]([C:20]2[O:14][C:13]([C:3]3[C:4]([C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=4)=[N:5][O:6][C:2]=3[CH3:1])=[N:15][N:16]=2)=[CH:23][CH:24]=[C:25]([Cl:27])[N:26]=1

Participants

3

Reactant 2

HCID 7279245-Methyl-3-phenyl-4-isoxazolecarbohydrazideHCID 8540472,6-Dichloronicotinic acid

Product 1

HCID 86613580HCID 86613580, compoundYield 35%

Procedure

As described for example 2, 5-methyl-3-phenyl-isoxazole-4-carboxylic acid hydrazide (400 mg, 1.84 mmol) was converted using 2,6-dichloronicotinic acid instead of o-toluic acid to the title compound (SiO2, heptane:ethyl acetate=80:20 to 40:60, 240 mg, 35%) which was obtained as a white solid. MS: m/e=373.0/375.0 [M+H]+.

Sources & evidence

ORD record
ord-285b436924bc4cb8b21a43dd35dbac62
Source dataset
uspto-grants-2011_06
Patent number
US07956074B2

Reaction notes

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