反应详情

A solution of 5-fluoro-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indole (D7) (143 mg) in ethyl acetate (8 mL) was passed through the H-cube at 1 mL/min with 1 Bar H2 pressure. The solution was evaporated and purified by chromatography on silica gel (elution with 0-50% ethyl acetate in hexane) to give the title compound (E5) as an off white solid (65 mg).

1. customThe solution was evaporated
2. custompurified by chromatography on silica gel (elution with 0-50% ethyl acetate in hexane)