反应详情

A solution of 6-fluoro-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indol-4-ol (D18) (380 mg, 1.082 mmol) in ethyl acetate (30 mL) was hydrogenated in an H-cube over a 10% palladium on charcoal catalyst. The resulting solution was concentrated. The product was purified by silica gel chromatography eluting with 10-100% ethyl acetate in hexane to yield the title compound (E9), (213 mg).

1. concentrationThe resulting solution was concentrated
2. customThe product was purified by silica gel chromatography
3. washeluting with 10-100% ethyl acetate in hexane