反应详情

4-[(phenylmethyl)oxy]-1-{4-[(phenylmethyl)oxy]phenyl}-1H-indole (D24) (143 mg, 0.352 mmoL) was dissolved in ethyl acetate (10 mL) and was hydrogenated at room temperature and atmospheric pressure in the presence of 10% palladium on charcoal (50% wet) (70 mg). After 28 hours the mixture was filtered and concentrated in vacuo. The crude product was purified by flash chromatography (Biotage SP4) eluting with a gradient of 0 to 100% ethyl acetate in hexane to give the title compound (E14), (55 mg).

1. customwas hydrogenated at room temperature
2. filtrationAfter 28 hours the mixture was filtered
3. concentrationconcentrated in vacuo
4. customThe crude product was purified by flash chromatography (Biotage SP4)
5. washeluting with a gradient of 0 to 100% ethyl acetate in hexane