Potassium Carbonate → HCID 21914252, compound

HRID 2421374Notes

Reaction equation

HRID 2421374 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[C:14]([OH:19])[CH:13]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Cl.Cl[CH2:28][CH2:29][N:30]1[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1>CC(C)=O>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[C:14]([O:19][CH2:28][CH2:29][N:30]3[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]3)[CH:13]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 74826Piperidine, 1-(2-chloroethyl)-, hydrochlorideHCID 21914298HCID 21914298, compound

Product 1

HCID 21914252HCID 21914252, compoundYield 106.6%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4-Bromo-3-hydroxyphenyl 4-methylbenzenesulfonate (17.6 g), potassium carbonate (7.32 g), 1-(2 chloroethyl)piperidine hydrochloride (9.2 g) and acetone (300 ml) were stirred at reflux for 3 h, the reaction mixture filtered and evaporated to give the product as light brown foam (24.2 g).

Workup

  1. temperatureat reflux for 3 h
  2. filtrationthe reaction mixture filtered
  3. customevaporated

Sources & evidence

ORD record
ord-76bc4e9254e84af185df9e47cb2dfd21
Source dataset
uspto-grants-2011_06
Patent number
US07956084B2

Reaction notes

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