Triethylamine → 1-Isopropylpyrrolidin-3-yl methanesulphonate

HRID 2421387Notes

Reaction equation

HRID 2421387 reaction equation
[CH:1]([N:4]1[CH2:8][CH2:7][CH:6]([OH:9])[CH2:5]1)([CH3:3])[CH3:2].C(N(CC)CC)C.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>C1(C)C=CC=CC=1>[CH3:17][S:18]([O:9][CH:6]1[CH2:7][CH2:8][N:4]([CH:1]([CH3:3])[CH3:2])[CH2:5]1)(=[O:20])=[O:19]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 113095221-Isopropyl-3-pyrrolidinol

Product 1

HCID 219143101-Isopropylpyrrolidin-3-yl methanesulphonate

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 1-isopropylpyrrolidin-3-ol (2.0 ml) and triethylamine (2.5 ml) in toluene (25 ml) was cooled to 0° C. and methanesulphonyl chloride (1.4 ml) was added dropwise with stirring. The mixture was allowed to warm to ambient temperature and stirred for a further 2 h. The reaction was filtered and the filtrate evaporated to an oil which was used immediately.

Workup

  1. stirringstirred for a further 2 h
  2. filtrationThe reaction was filtered
  3. customthe filtrate evaporated to an oil which

Sources & evidence

ORD record
ord-11369f871fa84c84a824fdd717950a0c
Source dataset
uspto-grants-2011_06
Patent number
US07956084B2

Reaction notes

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