4-Bromophenacyl bromide → 1-(4-Bromophenyl)-2-morpholinoethanone

HRID 2421394Notes

Reaction equation

HRID 2421394 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Br[CH2:8][C:9]([C:11]1[CH:16]=[CH:15][C:14]([Br:17])=[CH:13][CH:12]=1)=[O:10]>C1(C)C=CC=CC=1>[Br:17][C:14]1[CH:15]=[CH:16][C:11]([C:9](=[O:10])[CH2:8][N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 74544-Bromophenacyl bromideHCID 8083Morpholine

Product 1

HCID 4108821-(4-Bromophenyl)-2-morpholinoethanoneYield 101.3%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

Morpholine (4.35 g) in dry toluene (8 ml) was stirred during the addition of aliquots of 2-bromo-1-(4-bromophenyl)ethanone (6.95 g) in dry toluene (70 ml). The resulting precipitate was removed by filtration and the filtrate evaporated to give the product (J. Amer. Chem. Soc., 1940, 62, 2882) as a pale yellow solid (7.2 g).

Workup

  1. customThe resulting precipitate was removed by filtration
  2. customthe filtrate evaporated

Sources & evidence

ORD record
ord-b40b4806bb32466aa8de9b505667e52b
Source dataset
uspto-grants-2011_06
Patent number
US07956084B2

Reaction notes

Loading…