Hydrochloric Acid → HCID 86604847, compound

HRID 2421440Notes

Reaction equation

HRID 2421440 reaction equation
[N:1]([CH2:4][CH2:5][CH2:6][C:7]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[N:11]([C:12]([N:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH3:15])=[O:13])[N:10]=[C:9]([C:21]2[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:22]=2[F:28])[S:8]1)=[N+]=[N-].Cl>CO.[Pt]=O>[NH2:1][CH2:4][CH2:5][CH2:6][C:7]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[N:11]([C:12]([N:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH3:15])=[O:13])[N:10]=[C:9]([C:21]2[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:22]=2[F:28])[S:8]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86604845HCID 86604845, compound

Product 1

HCID 86604847HCID 86604847, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

To a solution of 2-(3-azidopropyl)-N-tert-butoxy-5-(2,5-difluorophenyl)-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide (0.032 g, 0.065 mmol) and platinum oxide (15 mg) in methanol (3 mL) was added HCl (5.3 M solution in dioxane, 0.05 mL). After stirring under a hydrogen balloon for 1 hour, the mixture was filtered and the filtrate was concentrated under reduced pressure to provide the product.

Workup

  1. filtrationthe mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customto provide the product

Sources & evidence

ORD record
ord-c58b014fb8c149d5988f8d031a85b3a8
Source dataset
uspto-grants-2011_06
Patent number
US07956073B2

Reaction notes

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