4-Aminopyridine → HCID 59161030, compound

HRID 242150Notes

Reaction equation

HRID 242150 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.Br[C:9]1[N:14]=[C:13]([CH2:15][OH:16])[CH:12]=[CH:11][CH:10]=1>C(#N)C>[N:5]1[CH:6]=[CH:7][C:2]([NH:1][C:9]2[N:14]=[C:13]([CH2:15][OH:16])[CH:12]=[CH:11][CH:10]=2)=[CH:3][CH:4]=1

Participants

4

Reactant 2

HCID 17274-AminopyridineHCID 3517811(6-Bromopyridin-2-yl)methanol

Product 1

HCID 59161030HCID 59161030, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

1.35 g (14.3 mmol) of 4-aminopyridine and 1.34 g (7.1 mmol) of (6-bromopyridin-2-yl)methanol are stirred at 150° C. for 4 h. After cooling to RT, 50 ml of acetonitrile are added to the reaction mixture, and the mixture is stirred for 20 min. The precipitate formed is filtered off with suction at 0° C. and washed with 10 ml of acetonitrile.

Workup

  1. customThe precipitate formed
  2. filtrationis filtered off with suction at 0° C.
  3. washwashed with 10 ml of acetonitrile

Sources & evidence

ORD record
ord-1f92ac167cba48b98aee4122d4b4cd33
Source dataset
uspto-grants-2014_02
Patent number
US08653109B2

Reaction notes

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