Potassium Hydroxide → HCID 66849176, compound

HRID 2421508Notes

Reaction equation

HRID 2421508 reaction equation
C[O:2][C:3]([C:5]1[C:9]([C:10]([F:13])([F:12])[F:11])=[N:8][N:7]([CH3:14])[N:6]=1)=[O:4].[OH-].[K+]>C1COCC1>[CH3:14][N:7]1[N:6]=[C:5]([C:3]([OH:4])=[O:2])[C:9]([C:10]([F:13])([F:11])[F:12])=[N:8]1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 67215212HCID 67215212, compound

Product 1

HCID 66849176HCID 66849176, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 2-methyl-5-trifluoromethyl-2H-1,2,3-triazole-4-carboxylic acid methyl ester [Compound Number 1.15] (2.09 g; 0.01 mol) and KOH (86%; 0.783 g; 1.2 eq.) in THF (50 ml) was heated at reflux temperature for 3.5 hours. The solution was evaporated, the residue was dissolved in water and acidified to pH 1-2 with HCl (1M). Evaporation of the aqueous solution followed by continuous extration in ethylacetate for 20 hours gave of Compound No 1.13 (2.11 g; 100%) as a crystalline solid.

Workup

  1. temperatureat reflux temperature for 3.5 hours
  2. customThe solution was evaporated
  3. dissolutionthe residue was dissolved in water
  4. customEvaporation of the aqueous solution
  5. customgave of Compound No 1.13 (2.11 g; 100%) as a crystalline solid

Sources & evidence

ORD record
ord-e021712e47b04bc1b5bbf1940a8077c5
Source dataset
uspto-grants-2011_06
Patent number
US07956194B2

Reaction notes

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