Ethyl 2-chloro-2-(methylsulfanyl)acetate → (3-Bromo-8-fluoro-quinolin-6-yloxy)-methylsulfanyl-acetic acid ethyl ester

HRID 2421529Notes

Reaction equation

HRID 2421529 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([OH:12])=[CH:7][C:6]=2[F:13].[CH2:14]([O:16][C:17](=[O:22])[CH:18](Cl)[S:19][CH3:20])[CH3:15]>>[CH2:14]([O:16][C:17](=[O:22])[CH:18]([O:12][C:8]1[CH:9]=[C:10]2[C:5](=[C:6]([F:13])[CH:7]=1)[N:4]=[CH:3][C:2]([Br:1])=[CH:11]2)[S:19][CH3:20])[CH3:15]

Participants

3

Reactant 2

HCID 10877535Ethyl 2-chloro-2-(methylsulfanyl)acetateHCID 672143473-Bromo-8-fluoro-6-quinolinol

Product 1

HCID 67213833(3-Bromo-8-fluoro-quinolin-6-yloxy)-methylsulfanyl-acetic acid ethyl ester

Procedure

In a similar procedure to Stage 2, Step 1 of Example 5, 3-bromo-8-fluoro-quinolin-6-ol was reacted with chloro-methylsulfanyl-acetic acid ethyl ester to give (3-Bromo-8-fluoro-quinolin-6-yloxy)-methylsulfanyl-acetic acid ethyl ester.

Sources & evidence

ORD record
ord-871a4f090ccf44719e64597f54e88aaf
Source dataset
uspto-grants-2011_06
Patent number
US07956188B2

Reaction notes

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