Ethyl 2-chloro-2-(methylsulfanyl)acetate → (3-Iodo-8-methyl quinolin-6-yloxy)-methylsulfanyl-acetic acid ethyl ester
Reaction equation
[I:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([OH:12])=[CH:7][C:6]=2[CH3:13].[CH2:14]([O:16][C:17](=[O:22])[CH:18](Cl)[S:19][CH3:20])[CH3:15]>>[CH2:14]([O:16][C:17](=[O:22])[CH:18]([O:12][C:8]1[CH:9]=[C:10]2[C:5](=[C:6]([CH3:13])[CH:7]=1)[N:4]=[CH:3][C:2]([I:1])=[CH:11]2)[S:19][CH3:20])[CH3:15]Participants
3
Procedure
In a similar procedure to Stage 2, Step 1 of Example 5, 3-iodo-8-methyl-quinolin-6-ol, was reacted with chloro-methylsulfanyl-acetic acid ethyl ester to give (3-iodo-8-methyl quinolin-6-yloxy)-methylsulfanyl-acetic acid ethyl ester as a yellow coloured solid (MH+ 418).
Sources & evidence
- ORD record
- ord-72415bfdade24819ac9d0187fe59656b
- Source dataset
- uspto-grants-2011_06
- Patent number
- US07956188B2
Reaction notes
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