Tert-Butylamine → HCID 67214351, compound

HRID 2421532Notes

Reaction equation

[I:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([O:12][CH:13]([S:17][CH3:18])[C:14]([OH:16])=O)=[CH:7][C:6]=2[CH3:19].[C:20]([NH2:24])([CH3:23])([CH3:22])[CH3:21]>>[C:20]([NH:24][C:14](=[O:16])[CH:13]([O:12][C:8]1[CH:9]=[C:10]2[C:5](=[C:6]([CH3:19])[CH:7]=1)[N:4]=[CH:3][C:2]([I:1])=[CH:11]2)[S:17][CH3:18])([CH3:23])([CH3:22])[CH3:21]

Participants

Reactant 2

HCID 6385Tert-Butylamine

HCID 67213779HCID 67213779, compound

Product 1

HCID 67214351HCID 67214351, compound

Procedure

In a similar procedure to Stage 2 of Example 1, (3-iodo-8-methyl-quinolin-6-yloxy)-methylsulfanyl-acetic acid was condensed with t-butylamine to give N-tert-Butyl-2-(3-iodo-8-methyl-quinolin-6-yloxy)-2-methylsulfanyl-acetamide as a white solid ([M+1]+ 445).

Sources & evidence

ORD record: ord-9f70b8803d524cc299b3622cec88d6f4
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07956188B2

Reaction notes

Loading…