反应详情

温度

50 °C

Into a 200 ml flask, 2.58 g of sodium borohydride and 25 g of dimethoxyethane were charged at room temperature and the obtained mixture was heated to 50° C. A mixed solution of 6.1 g of 2,3,5,6-tetrafluoroterephthalic acid and 20 g of dimethoxyethane was added dropwise to the mixture over 1 hour while stirring at the same temperature to effect the reaction for 7 hours at 60° C. After adding 25 g of toluene to the reaction mixture and cooling the obtained mixture at 25° C., 8.5 g of 35% by weight aqueous hydrochloric acid was added thereto dropwise over 1 hour at 25 to 30° C. and the resultant mixture was stirred and kept for 6 hours at 25 to 30° C. To the obtained mixture, 30 g of water was added. After leaving the mixture at rest, the mixture was separated to an organic layer and an aqueous layer. The aqueous layer was extracted twice with 30 g of ethyl acetate and the obtained oil layers were mixed with the organic layer previously obtained. The organic layer after mixing was washed with 10 g of a saturated potassium carbonate and then 10 g of water, and the organic layer was concentrated to obtain the solid containing 2,3,5,6-tetrafluorobenzenedimethanol. The yield of 2,3,5,6-tetrafluorobenzenedimethanol was 33%. Alternatively, 4-carboxy-2,3,5,6-tetrafluorobenzyl alcohol was formed as by-products in the yield of 29%, and a raw material 2,3,5,6-tetrafluoroterephthalic acid remained in 38%.

1. customthe reaction for 7 hours at 60° C
2. temperaturecooling the obtained mixture at 25° C.
3. waitkept for 6 hours at 25 to 30° C
4. customAfter leaving the mixture at rest
5. customthe mixture was separated to an organic layer
6. extractionThe aqueous layer was extracted twice with 30 g of ethyl acetate
7. additionthe obtained oil layers were mixed with the organic layer
8. custompreviously obtained
9. additionThe organic layer after mixing
10. washwas washed with 10 g of a saturated potassium carbonate
11. concentration10 g of water, and the organic layer was concentrated
12. customto obtain the solid