(1,1'-Biphenyl)-3-carboxylic acid → HCID 67214257, compound

HRID 2421602Notes

Reaction equation

HRID 2421602 reaction equation
[C:1]1([C:7]2[CH:8]=[C:9]([CH:13]=[CH:14][CH:15]=2)[C:10]([OH:12])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:16]1[CH2:18][CH:17]1[CH2:19][CH2:20][NH2:21]>>[CH2:16]1[CH2:18][CH:17]1[CH2:19][CH2:20][NH:21][C:10](=[O:12])[C:9]1[CH:13]=[CH:14][CH:15]=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:8]=1

Participants

3

Reactant 2

HCID 12854(1,1'-Biphenyl)-3-carboxylic acidHCID 10240761Cyclopropaneethanamine

Product 1

HCID 67214257HCID 67214257, compound

Procedure

Using Preparation Method 1, 3-phenylbenzoic acid was reacted with (2-cyclopropyl)ethylamine. The resulting reaction mixture was purified using SiO2 with CH2Cl2 100%. A white crystalline solid was obtained (69%). NMR 1H (ppm, CDCl3): 7.97 (s, 1H), 7.69 (d, J3=7.7 Hz, 2H), 7.60 (d, J3=7.2 Hz, 2H), 7.51-7.33 (m, 4H), 6.29 (br. s., 1H), 3.60-3.53 (m, 2H), 1.54 (quart., J3=7.0 Hz, 2H), 0.78-0.67 (m, 1H), 0.52-0.46 (m, 2H), 0.14-0.06 (m, 2H).

Workup

  1. customThe resulting reaction mixture
  2. customwas purified
  3. customA white crystalline solid was obtained (69%)

Sources & evidence

ORD record
ord-ed066d38a6c1498bbd15cd3a232c4b2e
Source dataset
uspto-grants-2011_06
Patent number
US07956216B2

Reaction notes

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