Isopropylamine → HCID 57762479, compound

HRID 2421603Notes

Reaction equation

HRID 2421603 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:3]=1[C:4]([OH:6])=O.[CH:12]([NH2:15])([CH3:14])[CH3:13]>>[CH:12]([NH:15][C:4](=[O:6])[C:3]1[C:7]([CH3:11])=[CH:8][CH:9]=[CH:10][C:2]=1[CH3:1])([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 6363IsopropylamineHCID 124392,6-Dimethylbenzoic acid

Product 1

HCID 57762479HCID 57762479, compound

Procedure

Using Preparation Method 1, 2,6-dimethylbenzoic acid was reacted with isopropylamine. The resulting reaction mixture was purified using SiO2 with CH2Cl2/MeOH 99:1. A white crystalline solid was obtained (73%). NMR 1H (ppm, CDCl3): 7.15-7.10 (m, 1H), 6.99 (d, J3=7.57 Hz, 2H), 5.44 (br. s., 1H), 4.40-4.24 (m, 1H), 2.31 (s, 6H), 1.24 (d, J3=6.58 Hz, 6H).

Workup

  1. customThe resulting reaction mixture
  2. customwas purified
  3. customA white crystalline solid was obtained (73%)

Sources & evidence

ORD record
ord-5058dd5d63024cb3a79c7bc7eb710a2a
Source dataset
uspto-grants-2011_06
Patent number
US07956216B2

Reaction notes

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