Isoamylamine → HCID 67214309, compound

HRID 2421604Notes

Reaction equation

HRID 2421604 reaction equation
[C:1]1([C:7]2[CH:8]=[C:9]([CH:13]=[CH:14][CH:15]=2)[C:10]([OH:12])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:16]([NH2:21])[CH2:17][CH:18]([CH3:20])[CH3:19]>>[CH2:16]([NH:21][C:10](=[O:12])[C:9]1[CH:13]=[CH:14][CH:15]=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:8]=1)[CH2:17][CH:18]([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 7894IsoamylamineHCID 12854(1,1'-Biphenyl)-3-carboxylic acid

Product 1

HCID 67214309HCID 67214309, compound

Procedure

Using Preparation Method 1, 3-phenylbenzoic acid was reacted with isoamylamine. The resulting reaction mixture was purified using SiO2 with CH2Cl2 100%. An off-white crystalline solid was obtained (61%). NMR 1H (ppm, CDCl3): 7.96 (s, 1H), 7.69 (d, J3=8.3 Hz, 2H), 7.59 (d, J3=7.2 Hz, 2H), 7.50-7.33 (m, 4H), 6.10 (br. s., 1H), 3.52-3.45 (m, 2H), 1.76-1.64 (m, 1H), 1.52 (quart., 2H), 0.95 (d, J3=6.6 Hz, 6H).

Workup

  1. customThe resulting reaction mixture
  2. customwas purified
  3. customAn off-white crystalline solid was obtained (61%)

Sources & evidence

ORD record
ord-f33012c2c6974d6ab59b680627780fc6
Source dataset
uspto-grants-2011_06
Patent number
US07956216B2

Reaction notes

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