Isoamylamine → HCID 835408, compound

HRID 2421605Notes

Reaction equation

HRID 2421605 reaction equation
[C:1]1([C:7]2[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:16]([NH2:21])[CH2:17][CH:18]([CH3:20])[CH3:19]>>[CH2:16]([NH:21][C:11](=[O:13])[C:10]1[CH:9]=[CH:8][C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:15][CH:14]=1)[CH2:17][CH:18]([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 7894IsoamylamineHCID 66724(1,1'-Biphenyl)-4-carboxylic acid

Product 1

HCID 835408HCID 835408, compound

Procedure

Using Preparation Method 1, 4-phenylbenzoic acid was reacted with isoamylamine. The resulting reaction mixture was purified using SiO2 with CH2Cl2 100%. A white crystalline solid was obtained (29%). NMR 1H (ppm, CDCl3): 7.81 (d, J3=8.3 Hz, 2H), 7.65-7.58 (m, 4H), 7.47-7.34 (m, 3H), 6.06 (br. s., 1H), 3.53-3.36 (m, 2H), 1.74-1.65 (m, 1H), 1.52 (quart., J3=6.7 Hz, 2H), 0.96 (d, J3=6.6 Hz).

Workup

  1. customThe resulting reaction mixture
  2. customwas purified
  3. customA white crystalline solid was obtained (29%)

Sources & evidence

ORD record
ord-a3e7d81a1c74471bb272fc9ee9067316
Source dataset
uspto-grants-2011_06
Patent number
US07956216B2

Reaction notes

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