Trifluoroacetic acid → HCID 67215062, compound

HRID 2421618Notes

Reaction equation

HRID 2421618 reaction equation
C([NH:8][CH2:9][CH2:10][S:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)(OC(C)(C)C)=O.[C:19]([OH:25])([C:21]([F:24])([F:23])[F:22])=[O:20]>C(Cl)Cl>[F:22][C:21]([F:24])([F:23])[C:19]([O-:25])=[O:20].[CH2:12]([S:11][CH2:10][CH2:9][NH3+:8])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 29973008tert-Butyl [2-(benzylsulfanyl)ethyl]carbamate

Product 1

HCID 67215062HCID 67215062, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

N-Boc-2-Benzylsulfanyl-ethylamine (56 mg, 0.21 mmol) in 1 mL dry CH2Cl2 was treated with 0.5 mL of TFA at 0° C. After reaction completion (checked by TLC), the reaction mixture was concentrated in vacuo. The residue was dissolved in toluene and concentrated. This procedure was repeated two more times and the residue was dried under high vacuum and used directly in the next step without further purification.

Workup

  1. customAfter reaction completion (checked by TLC)
  2. concentrationthe reaction mixture was concentrated in vacuo
  3. dissolutionThe residue was dissolved in toluene
  4. concentrationconcentrated
  5. customthe residue was dried under high vacuum
  6. customused directly in the next step without further purification

Sources & evidence

ORD record
ord-137d7520ee7049d3b819010a6ce8f39a
Source dataset
uspto-grants-2011_06
Patent number
US07956216B2

Reaction notes

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