Hydrochloric Acid → HCID 5162089, compound

HRID 2421625Notes

Reaction equation

HRID 2421625 reaction equation
C[O:2][C:3](=[O:18])[C:4]1[CH:9]=[CH:8][C:7]([CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:6][CH:5]=1.[OH-].[Na+].Cl>CCO>[CH:10]([C:7]1[CH:6]=[CH:5][C:4]([C:3]([OH:18])=[O:2])=[CH:9][CH:8]=1)=[CH:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 53426079Methyl 4-(2-phenylethenyl)benzoate

Product 1

HCID 5162089HCID 5162089, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

73A (80 mg, 0.34 mmol) was suspended in EtOH (0.5 mL) and aqueous NaOH (1 M, 2 mL) and was heated to 80° C. for one hour. Upon cooling to room temperature, the solution was acidified with HCl (concentrated), was cooled to 0° C., and was filtered. The white crystalline precipitate was dried under vacuum (75 mg, quant.). NMR 1H (ppm, CDCl3): 7.93 (d, J3=8.3 Hz, 2H), 7.56-7.53 (m, 4H), 7.33 (t, J3=7.4 Hz, 2H), 7.27-7.11 (m, 3H).

Workup

  1. temperaturewas cooled to 0° C.
  2. filtrationwas filtered
  3. customThe white crystalline precipitate was dried under vacuum (75 mg, quant.)

Sources & evidence

ORD record
ord-2e3b6e15ada34a79b39357aac8a7f076
Source dataset
uspto-grants-2011_06
Patent number
US07956216B2

Reaction notes

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