Hydrochloric Acid → HCID 308466, compound

HRID 2421631Notes

Reaction equation

HRID 2421631 reaction equation
C[O:2][C:3](=[O:18])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:5]=1.[OH-].[Na+].Cl>CCO>[CH2:10]([C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=1)[C:3]([OH:18])=[O:2])[CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 53961900Benzoic acid,3-(2-phenylethyl)-,methyl ester

Product 1

HCID 308466HCID 308466, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

75B (660 mg, 2.75 mmol) was suspended in EtOH (2 mL) and aqueous NaOH (1 M, 6 mL) and was heated to 80° C. for thirty minutes. Upon cooling to room temperature, the solution was acidified with HCl (concentrated), was cooled to 0° C., and was filtered. The white crystalline precipitate was dried under vacuum (356 mg, 57%). NMR 1H (ppm, CDCl3): 7.96-7.91 (m, 2H), 7.40-7.36 (m, 2H), 7.30-7.15 (n, 5H), 3.02-2.90 (m, 4H).

Workup

  1. temperaturewas cooled to 0° C.
  2. filtrationwas filtered
  3. customThe white crystalline precipitate was dried under vacuum (356 mg, 57%)

Sources & evidence

ORD record
ord-a749398339774ef691d05ceba1ae8f2f
Source dataset
uspto-grants-2011_06
Patent number
US07956216B2

Reaction notes

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