Hydrochloric Acid → HCID 21063832, compound

HRID 2421646Notes

Reaction equation

HRID 2421646 reaction equation
C[O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][CH2:11][CH:12]([CH3:14])[CH3:13])[CH:5]=1.[OH-].[Na+].Cl>CCO>[CH2:10]([C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=1)[C:3]([OH:15])=[O:2])[CH2:11][CH:12]([CH3:14])[CH3:13]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 21063916HCID 21063916, compound

Product 1

HCID 21063832HCID 21063832, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

96A (824 mg, 4 mmol) was suspended in EtOH (4 mL) and aqueous NaOH (1 M, 20 mL) and was heated under reflux conditions for sixty minutes. Upon cooling to room temperature, the solution was acidified with HCl (conc.), was cooled to 0° C., and was filtered. The white crystalline precipitate was dried under vacuum (633 mg, 82%). NMR 1H (ppm, CDCl3): 7.94-7.91 (m, 2H), 7.42 (d, J3=7.6 Hz, 1H), 7.36 (t, J3=7.7 Hz, 1H), 2.69-2.64 (m, 2H), 1.62-1.49 (m, 3H), 0.94 (d, J3=6.3 Hz, 6H).

Workup

  1. temperaturewas cooled to 0° C.
  2. filtrationwas filtered
  3. customThe white crystalline precipitate was dried under vacuum (633 mg, 82%)

Sources & evidence

ORD record
ord-ced3f636b8cc4794b8f49f7a585f7f26
Source dataset
uspto-grants-2011_06
Patent number
US07956216B2

Reaction notes

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