Hydrogen Peroxide → 3-Fluoroisonicotinic acid 1-oxide
Reaction equation
[F:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[OH:11]O>C(O)(=O)C>[F:1][C:2]1[CH:10]=[N+:9]([O-:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 75 °C
Procedure
To a solution of 3-fluoroisonicotinic acid (5.0 g, 35.33 mmol) in acetic acid (25 ml) was added hydrogen peroxide (6 ml). The reaction mixture was stirred at 70-80° C. overnight. The solvent was removed to obtain 5.5 g of 3-fluoroisonicotinic acid 1-oxide in quantitative yield.
Workup
- customThe solvent was removed
Sources & evidence
- ORD record
- ord-2f3287c5382e4a44a00725760fb2d58c
- Source dataset
- uspto-grants-2011_06
- Patent number
- US07956191B2
Reaction notes
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