反应详情

5-Propyl-1-[2′-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-pyrazole-3-carboxylic acid ethyl ester (400 mg, 607 μmol) was dissolved in THF (12.0 mL, 148 mmol). A solution of LiOH monohydrate (127 mg, 3.04 mmol) in water (4.0 mL, 222 mmol) was then added and the mixture was stirred at room temperature for about 19 hours. The mixture was then heated to 60° C. overnight. LCMS showed that the reaction was complete, but that two additional side products had also formed. The mixture was partitioned between EtOAc and a saturated ammonium chloride solution. The EtOAc layer was dried over Na2SO4 and concentrated to yield the title compound (340 mg). LCMS showed that the side products were no longer present.

1. temperatureThe mixture was then heated to 60° C. overnight
2. customthat two additional side products had also formed
3. customThe mixture was partitioned between EtOAc
4. dry with materialThe EtOAc layer was dried over Na2SO4
5. concentrationconcentrated