反应详情

温度

35 °C

4-(benzyloxy)-4-oxobutanoic acid (6.16 g, 1 eq, from Example 1a) was dissolved in toluene (20 mL) and placed in a 300 mL round bottom flask, fitted with a condenser. While the reaction was stirred under inert atmosphere, thionyl chloride (5.30 g, 1.5 eq) was added. A few drops of DMF were also added and tire reaction mixture was heated to 35° C. for 45 minutes and then to 60° C. for 2 hours. The solution was concentrated to 6.71 g of brownish oil.

1. customplaced in a 300 mL round bottom flask
2. customfitted with a condenser
3. additionwas added
4. customtire reaction mixture
5. concentrationThe solution was concentrated to 6.71 g of brownish oil