Methylamine → HCID 67241489, compound

HRID 2421831Notes

Reaction equation

HRID 2421831 reaction equation
C1(O[C:8]([N:10]2[C:16]([CH3:17])=[CH:15][C:14]3[CH:18]=[CH:19][C:20]([Cl:22])=[CH:21][C:13]=3[C:12]([C:23]3[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[C:25]([CH3:32])[CH:24]=3)=[N:11]2)=[O:9])C=CC=CC=1.[CH3:33][NH2:34]>C(O)C>[CH3:33][NH:34][C:8]([N:10]1[C:16]([CH3:17])=[CH:15][C:14]2[CH:18]=[CH:19][C:20]([Cl:22])=[CH:21][C:13]=2[C:12]([C:23]2[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[C:25]([CH3:32])[CH:24]=2)=[N:11]1)=[O:9]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 67243508HCID 67243508, compound

Product 1

HCID 67241489HCID 67241489, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

11.86 g (26.4 mmoles) of 8-chloro-4-methyl-1-(3-methyl-4-nitrophenyl)-3H-2,3-benzodiazepine-3-carboxylic acid phenyl ester are stirred with a solution of 43 ml of methylamine (˜8M) in ethanol at room temperature for 24 hours. The separated crystals are filtered off and washed with ethanol. Thus 8.87 g (87%) of the desired compound (yellow) melting at 196-198° C. are obtained.

Workup

  1. filtrationThe separated crystals are filtered off
  2. washwashed with ethanol

Sources & evidence

ORD record
ord-be94987264fd42c9b9aa3e96370d02a7
Source dataset
uspto-grants-2011_06
Patent number
US07960375B2

Reaction notes

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