Cyclopropylamine → HCID 67243228, compound

HRID 2421832Notes

Reaction equation

HRID 2421832 reaction equation
C1([O:7][C:8]([N:10]2[C:16]([CH3:17])=[CH:15][C:14]3[CH:18]=[CH:19][C:20]([Cl:22])=[CH:21][C:13]=3[C:12]([C:23]3[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[C:25]([CH3:32])[CH:24]=3)=[N:11]2)=O)C=CC=CC=1.[CH:33]1([NH2:36])[CH2:35][CH2:34]1>>[CH:33]1([NH:36][C:8]([N:10]2[C:16]([CH3:17])=[CH:15][C:14]3[CH:18]=[CH:19][C:20]([Cl:22])=[CH:21][C:13]=3[C:12]([C:23]3[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[C:25]([CH3:32])[CH:24]=3)=[N:11]2)=[O:7])[CH2:35][CH2:34]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 67243508HCID 67243508, compound

Product 1

HCID 67243228HCID 67243228, compoundYield 59%

Procedure

2.07 g (4.6 mmoles) 8-chloro-4-methyl-1-(3-methyl-4-nitrophenyl)-3H-2,3-benzodiazepine-3-carboxylic acid phenyl ester are boiled in 10 ml of cyclopropylamine for 10 hours. The separated crystals are filtered off, and the crude product is re-crystallized from ethanol. Thus 1.12 g (59%) of the desired compound melting at 221-223° C. is obtained.

Workup

  1. filtrationThe separated crystals are filtered off
  2. customthe crude product is re-crystallized from ethanol

Sources & evidence

ORD record
ord-7e3eb58fe9534808afe9df46a8dc10ce
Source dataset
uspto-grants-2011_06
Patent number
US07960375B2

Reaction notes

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