Hydrochloric Acid → HCID 67243526, compound

HRID 2421858Notes

Reaction equation

HRID 2421858 reaction equation
Cl.[Cl:2][C:3]1[C:13]2[S:12][CH2:11][C@H:10]([NH:14]C(=O)OC(C)(C)C)[C:9](=[O:22])[NH:8][C:7]=2[CH:6]=[C:5]([C:23]([F:26])([F:25])[F:24])[CH:4]=1>O1CCOCC1>[ClH:2].[NH2:14][C@@H:10]1[C:9](=[O:22])[NH:8][C:7]2[CH:6]=[C:5]([C:23]([F:26])([F:25])[F:24])[CH:4]=[C:3]([Cl:2])[C:13]=2[S:12][CH2:11]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71158155HCID 71158155, compound

Product 1

HCID 67243526HCID 67243526, compoundYield 183.8%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

11 mL of a solution of hydrogen chloride in dioxane (4 M) are added to a 25 mL round-bottomed flask containing 582 mg of 15 (1.47 mmol). The mixture is stirred for 4 hours at room temperature under argon. A white precipitate forms, which is filtered off by suction and washed with 3 mL of dioxane and then 5 mL of isopropyl ether. 450 mg of amine 16 are thus obtained in the form of the hydrochloride.

Workup

  1. filtrationA white precipitate forms, which is filtered off by suction
  2. washwashed with 3 mL of dioxane

Sources & evidence

ORD record
ord-89dcd2834d0e4ee2be3dd87c51f69c5f
Source dataset
uspto-grants-2011_06
Patent number
US07960373B2

Reaction notes

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