反应详情

温度

100 °C

The product from Step 1 was dissolved in MeOH (1 mL) and water (0.5 mL) and placed in a 2 mL microwave vial with a magnetic stirrer bar. Lithium hydroxide (40 mg, 0.96 mmol) was added to the vial. The vial was capped and vortexed to dissolve the LiOH, and the reaction was heated for 5 minutes at 100° C. under microwave irradiation. The reaction was quenched by the addition of aqueous 1M HCl (960 μL). The volatiles were evaporated to dryness. This yielded a white/yellow solid which was used without further purification. LCMS (+ESI) m/z=285.0 [M+H]+.

1. customThe vial was capped
2. customThe reaction was quenched by the addition of aqueous 1M HCl (960 μL)
3. customThe volatiles were evaporated to dryness
4. customThis yielded a white/yellow solid which
5. customwas used without further purification